R/GA's EMEA boss Matt Lodder is to depart after seven and a half years at the agency.
The Drum understands that Lodder has left to explore other leadership roles.
A spokesperson said: "It was an incredibly difficult decision but, given the strength of the new leadership in place, now feels like the best time to allow a new leader to join the agency in EMEA and lead the next generation of growth."
Lodder led the agency's teams in London, Berlin and Bucharest and is credited with a four year period of double-digit growth in the EMEA region and its expansion to Istanbul. During his tenure, R/GA London secured major creative awards, including Gold Lions, Clios, Pencils, LIA’s and a Eurobest Grand Prix.
The Interpublic agency's chief executive Sean Lyons and the global exec board will work with the global team to appoint a replacement.
EMEA chief creative officer Andre Le Masurier (who joined earlier this year) and executive strategy director Rob Campbell will support the team during the transition period.
Before joining R/GA is 2012, Lodder was a global program director for Nike at AKQA.
Lodder previously told The Drum he was not worried about the impending threat of consultancies pushing into the agency space. “Why would we be frightened by something that doesn’t have creativity to the core?”