Vogue’s longest serving editor Alexandra Shulman is stepping down in June after a quarter of a century in the role.
It is not yet known where Shulman will be moving to. She said simply she wants to "experience a different life" and looks "forward to a future separate to Vogue".
An announcement regarding a successor will be made in due course. The position will be advertised externally and will be open to candidates from both inside and outside the company, the publisher said.
Nicholas Coleridge, managing director of Condé Nast Britain, said: “This is an announcement I hoped never to have to make. Alexandra Shulman, editor-in-chief of British Vogue for a quarter of a century, told me before Christmas that she had decided to stand down from Vogue in six months time.
"Shulman has been the longest serving and most successful editor of Vogue in its 100 year history. She has edited the title for a quarter of its existence, through its period of highest ever circulation, and its simultaneous transformation into a global digital brand.
"It is impossible to sufficiently express the contribution she has made to Vogue, to Condé Nast and to the British fashion industry."
Shulman added: “I have edited British Vogue for 25 years almost to the day, and to have steered it during our spectacular centenary has been one of the greatest privileges. During that time I have worked with an unparalleled collection of talent both inside and outside the magazine and have been lucky enough to see both Vogue and the British fashion industry expand and flourish.
"It has been very hard to find a rational reason to leave what is unquestionably a fascinating and rewarding role but last autumn I realised that I very much wanted to experience a different life and look forward to a future separate to Vogue.
"My career at Condé Nast has been everything I could have wished of it and my heartfelt thanks go to Nicholas Coleridge and Jonathan Newhouse for giving me so many opportunities, trusting me to take care of the precious cargo that is Vogue and allowing me the freedom to do the job exactly how I wanted."