Mark Addicks, the chief marketing officer at General Mills since 2004, is set to retire.
Addicks, who has been at the company for 26 years, will be replaced by Ann Simonds, president of General Mills' baking products division.
General Mills chief executive Ken Powell said: "Mark has been a remarkable visionary who has helped shape the purpose of our brands to best serve our consumers.
"We thank Mark for his incredible contributions to General Mills over 26 terrific years. We know he will continue to be a marketing thought leader and brand-building visionary even in his retirement."
Earlier this year, General Mills named Jennifer Jorgensen as its new marketing director.