For me it has to be Evernote as my number one iPad app.
I like taking notes at events or meetings in my Moleskine notebook but sometimes I know what I write will need to be shared with colleagues quickly or be available to me to search through in future and Evernote cleverly fills that gap.
With the ability to sync to the cloud, I can then review items on my iPhone while I'm out and later at home or in the office I can amend and re-arrange my notes.
As Evernote allows me to tag and categorise notes - like a blog - I can easily group notes and search for them in the future.
The clever thing is that it's not just for notes - it acts as an online repository for scans of business cards, receipts and often most importantly, tickets for travelling.
When I'm preparing a quote, I can start the main items off on my iPhone, work it up on the iPad and then transfer it over to Word when I get to the office. So it's not that the iPad app itself is indispensable, but it's the one app that sits outside of Mail, Safari and Twitter I couldn't do without.
That's not very designer-led, but without events, meetings and quotes, there'd be no design business to speak of.
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